Cheminformatic Tools and Databases for Pharmacology

session 35838 - Total of 2 hits - Display   hits per page:

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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
M VALBENAZINE (is an active metabolite)

VALBENAZINE


ATC N07XX13

NERVOUS SYSTEM
VESICULAR MONOAMINE TRANSPORTER 2 (VMAT2) INHIBITOR (KI = 3 NANOMOLAR)
TREATMENT OF ADULTS WITH TARDIVE DYSKINESIA

-

Tmax 6 HOUR

PPB 64 PERCENT

HT 22 HOUR

VESICULAR MONOAMINE TRANSPORTER 2 (VMAT2)

TRANSPORTER VMAT2_HUMAN INHIBITOR Q05940ANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank

2 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
VALBENAZINE (has an active metabolite)

VALBENAZINE


ATC N07XX13

NERVOUS SYSTEM
VESICULAR MONOAMINE TRANSPORTER 2 (VMAT2) INHIBITOR (KI = 150 NANOMOLAR)
TREATMENT OF ADULTS WITH TARDIVE DYSKINESIA

ORAL

Tmax 0.75 HOUR

F 49 PERCENT

VD 92 LITER

PPB 99 PERCENT

Cl 7.2 LITER / HOUR

HT 15 HOUR

SOLUBILITY SLIGHTLY SOLUBLE IN WATER

VESICULAR MONOAMINE TRANSPORTER 2 (VMAT2)

TRANSPORTER VMAT2_HUMAN INHIBITOR Q05940ANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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