| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| VOXILAPREVIR
| VOXILAPREVIR | ANTIINFECTIVES | ORAL | Cmax 221 NANOMOLAR Tmax 4 HOUR PPB 99 PERCENT HT 33 HOUR SOLUBILITY IS PRACTICALLY INSOLUBLE (LESS THAN 0.1 MG/ML) BELOW PH 6.8 | NS3/4A PROTEASE PDB 6NZT (CRYSTAL STRUCTURE OF HCV NS3, 4A PROTEASE IN COMPLEX WITH VOXILAPREVIR) LIGAND CODE = L9P (link to the list of PDB complexes) Download experimental 3D coordinates of L9P with added hydrogens | Genome polyprotein UNIPROT P26663 -- Genome polyprotein UNIPROT Q81495 more at DrugCentral | EMA | |||
