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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
NALDEMEDINE

NALDEMEDINE


ATC A06AH05

METABOLISM
OPIOID ANTAGONIST INDICATED FOR THE TREATMENT OF OPIOID-INDUCED CONSTIPATION (OIC) IN ADULT PATIENTS WITH CHRONIC NON-CANCER PAIN
DERIVATIVE OF NALTREXONE

ORAL

Tmax 0.75 HOUR

VD 155 LITER

PPB 93.5 PERCENT

HT 11 HOUR

SOLUBILITY SLIGHTLY SOLUBLE IN WATER

MU OPIOID RECEPTOR
DELTA OPIOID RECEPTOR
KAPPA OPIOID RECEPTOR

GPCR OPRM_HUMAN ANTAGONIST P35372ANSM (in French)

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