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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ENASIDENIB
| ENASIDENIB | ANTINEOPLASTIC | ORAL | Cmax 27.4 MICROMOLAR Tmax 4 HOUR F 57 PERCENT VD 55.8 LITER PPB 98.5 PERCENT Cl 0.74 LITER / HOUR HT 137 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER (LESS THAN 74 MCG/ML) | ISOCITRATE DEHYDROGENASE-2 (IDH2) PDB 5I96 (CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL ISOCITRATE DEHYDROGENASE (IDH2) R140Q MUTANT HOMODIMER IN COMPLEX WITH AG-221 (ENASIDENIB) INHIBITOR.) LIGAND CODE = 69Q (link to the list of PDB complexes) Download experimental 3D coordinates of 69Q with added hydrogens | Isocitrate dehydrogenase NADP, mitochondrial UNIPROT P48735 IDH2 more at DrugCentral | EMA | |||
