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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| DELAFLOXACIN
| DELAFLOXACIN | ANTIINFECTIVES | ORAL INTRAVENOUS | Cmax 20.3 MICROMOLAR Tmax 1 HOUR F 58.8 PERCENT VD 39 LITER PPB 84 PERCENT Cl 14.1 LITER / HOUR HT 3.7 HOUR | DNA GYRASE (TOPOISOMERASE II) BACTERIAL TOPOISOMERASE IV PDB 8C41 (HIGH RESOLUTION STRUCTURE OF THE STREPTOCOCCUS PNEUMONIAE TOPOISOMERASE IV-DNA COMPLEX WITH THE NOVEL FLUOROQUINOLONE DELAFLOXACIN) LIGAND CODE = TE9 (link to the list of PDB complexes) Download experimental 3D coordinates of TE9 with added hydrogens | Unknown more at DrugCentral | EMA | |||
