| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| NIRAPARIB
| NIRAPARIB | ANTINEOPLASTIC | ORAL | Cmax 2.51 MICROMOLAR Tmax 3 HOUR F 73 PERCENT VD 1220 LITER PPB 83 PERCENT Cl 16.2 LITER / HOUR HT 36 HOUR SOLUBILITY AQUEOUS OF 0.7 MG/ML TO 1.1 MG/ML ACROSS THE PHYSIOLOGICAL PH RANGE | POLY(ADP-RIBOSE) POLYMERASE (PARP) PARP-1 PARP-2 PDB 4R6E (HUMAN ARTD1 (PARP1) - CATALYTIC DOMAIN IN COMPLEX WITH INHIBITOR NIRAPARIB) LIGAND CODE = 3JD (link to the list of PDB complexes) Download experimental 3D coordinates of 3JD with added hydrogens | Poly ADP-ribose polymerase 2 UNIPROT Q9UGN5 PARP2 -- Poly ADP-ribose polymerase 1 UNIPROT P09874 PARP1 more at DrugCentral | EMA | |||
