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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
NERATINIB

NERATINIB


ATC L01XE45

ANTINEOPLASTIC
TREATMENT OF ADULT PATIENTS WITH EARLY STAGE HER2-OVEREXPRESSED/AMPLIFIED BREAST CANCER
EGFR KINASE INHIBITOR
HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2 (HER2) AND HER4 INHIBITOR

ORAL

Tmax 5 HOUR

VD 6433 LITER

PPB 99 PERCENT

Cl 281 LITER / HOUR

HT 14.6 HOUR

SOLUBILITY SPARINGLY SOLUBLE AT PH 1.2 (32.90 MG/ML) AND INSOLUBLE AT APPROXIMATE PH 5.0 AND ABOVE (0.08 MG/ML OR LESS)

EGFR
HER2
HER4

ENZYME EGFR_HUMAN INHIBITOR P00533 ERBB2_HUMAN INHIBITOR P04626 ERBB4_HUMAN INHIBITOR Q15303ANSM (in French)

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