MIDOSTAURIN (has an active metabolite) | MIDOSTAURIN | ATC L01EX10
ANTINEOPLASTIC TREATMENT OF ACUTE MYELOID LEUKEMIA (AML) OR AGGRESSIVE SYSTEMIC MASTOCYTOSIS (ASM) MULTIKINASE TYROSINE KINASE INHIBITOR (FLT3, FLT3 MUTANT KINASES (ITD AND TKD), KIT (WILD TYPE AND D816V MUTANT), PDGFR ALPHA/BETA, VEGFR2, AS WELL AS MEMBERS OF THE SERINE/THREONINE KINASE PKC (PROTEIN KINASE C) FAMILY) | ORAL | Tmax 2 HOUR VD 95.2 LITER PPB 99.8 PERCENT HT 21 HOUR | FLT3 KINASE FLT3 MUTANT KINASES KIT PDGFR VEGFR2 SERINE/THREONINE KINASE PKC PDB 4NCT (HUMAN DYRK1A IN COMPLEX WITH PKC412) LIGAND CODE = 2K2 (link to the list of PDB complexes) Download experimental 3D coordinates of 2K2 with added hydrogens | Receptor-type tyrosine-protein kinase FLT3 UNIPROT P36888 FLT3 more at DrugCentral | EMA ANSM (in French) Inxight Drugs Dailymed Drugs.com SIDER side effects Chemical Probes Portal ChEMBL BindingDB DrugBank |