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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
SAFINAMIDE

SAFINAMIDE


ATC N04BD03

NERVOUS SYSTEM
ADJUNCTIVE TREATMENT TO LEVODOPA/CARBIDOPA IN PATIENTS WITH PARKINSON'S DISEASE
MONOAMINE OXIDASE TYPE B (MAO-B) INHIBITOR
BLOCKS THE CATABOLISM OF DOPAMINE
1000-FOLD SELECTIVITY OVER MAO-A

ORAL

Tmax 2.5 HOUR

F 95 PERCENT

VD 165 LITER

PPB 88 PERCENT

Cl 4.6 LITER / HOUR

HT 23 HOUR

SOLUBILITY SOLUBLE IN WATER BUT SHOWS LOW SOLUBILITY (<0.4 MG/ML) AT PH 6.8 AND 7.5

MONOAMINE OXIDASE TYPE B (MAO-B)

ENZYME AOFB_HUMAN INHIBITOR P27338ANSM (in French)

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