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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
RUCAPARIB

RUCAPARIB


ATC L01XX55

ANTINEOPLASTIC
TREATMENT OF OVARIAN CANCER WITH DELETERIOUS BRCA MUTATION
POLY (ADP-RIBOSE) POLYMERASE (PARP) INHIBITOR

ORAL

Cmax 6 MICROMOLAR

Tmax 1.9 HOUR

F 36 PERCENT

VD 187 LITER

PPB 70 PERCENT

Cl 47 LITER / HOUR

HT 17 HOUR

SOLUBILITY PH-INDEPENDENT LOW SOLUBILITY OF APPROXIMATELY 1 MG/ML ACROSS THE PHYSIOLOGICAL PH RANGE

POLY (ADP-RIBOSE) POLYMERASE (PARP)
PARP-1
PARP-2
PARP-3

PDB 4BJC (CRYSTAL STRUCTURE OF HUMAN TANKYRASE 2 IN COMPLEX WITH RUCAPARIB)

LIGAND CODE = RPB (link to the list of PDB complexes)

Download experimental 3D coordinates of RPB with added hydrogens

ENZYME PARP1_HUMAN INHIBITOR P09874 PARP2_HUMAN INHIBITOR Q9UGN5 PARP3_HUMAN INHIBITOR Q9Y6F1ANSM (in French)

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