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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| RUCAPARIB
| RUCAPARIB | ANTINEOPLASTIC | ORAL | Cmax 6 MICROMOLAR Tmax 1.9 HOUR F 36 PERCENT VD 187 LITER PPB 70 PERCENT Cl 47 LITER / HOUR HT 17 HOUR SOLUBILITY PH-INDEPENDENT LOW SOLUBILITY OF APPROXIMATELY 1 MG/ML ACROSS THE PHYSIOLOGICAL PH RANGE | POLY (ADP-RIBOSE) POLYMERASE (PARP) PARP-1 PARP-2 PARP-3 PDB 4BJC (CRYSTAL STRUCTURE OF HUMAN TANKYRASE 2 IN COMPLEX WITH RUCAPARIB) LIGAND CODE = RPB (link to the list of PDB complexes) Download experimental 3D coordinates of RPB with added hydrogens | Poly ADP-ribose polymerase 2 UNIPROT Q9UGN5 PARP2 -- Poly ADP-ribose polymerase 1 UNIPROT P09874 PARP1 more at DrugCentral | EMA | |||
