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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ALECTINIB
| ALECTINIB | ANTINEOPLASTIC | ORAL | Cmax 1.38 MICROMOLAR Tmax 4 HOUR F 37 PERCENT VD 4016 LITER PPB 99 PERCENT Cl 81.9 LITER / HOUR HT 33 HOUR | ALK KINASE RET KINASE PDB 3AOX (X-RAY CRYSTAL STRUCTURE OF HUMAN ANAPLASTIC LYMPHOMA KINASE IN COMPLEX WITH CH5424802) LIGAND CODE = EMH (link to the list of PDB complexes) Download experimental 3D coordinates of EMH with added hydrogens | ALK tyrosine kinase receptor UNIPROT Q9UM73 ALK -- Proto-oncogene tyrosine-protein kinase receptor Ret UNIPROT P07949 RET more at DrugCentral | EMA | |||
