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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| GRAZOPREVIR
| GRAZOPREVIR | ANTIINFECTIVES | ORAL | Cmax 215 NANOMOLAR Tmax 2 HOUR VD 1250 LITER PPB 98.8 PERCENT HT 31 HOUR SOLUBILITY PRACTICALLY INSOLUBLE IN WATER | NS3/4A PROTEASE PDB 3SUF (CRYSTAL STRUCTURE OF NS3, 4A PROTEASE VARIANT D168A IN COMPLEX WITH MK-5172) LIGAND CODE = SUE (link to the list of PDB complexes) Download experimental 3D coordinates of SUE with added hydrogens | Genome polyprotein UNIPROT P26663 -- Genome polyprotein UNIPROT P27958 more at DrugCentral | EMA | |||
