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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
OSIMERTINIB

OSIMERTINIB


ATC L01EB04

ANTINEOPLASTIC
COVALENT KINASE INHIBITOR
TREATMENT OF METASTATIC EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) T790M MUTATION POSITIVE NON-SMALL CELL LUNG CANCER (NSCLC)
ALSO INHIBITED THE ACTIVITY OF HER2, HER3, HER4, ACK1 AND BLK

ORAL

Tmax 6 HOUR

VD 986 LITER

Cl 14.2 LITER / HOUR

HT 48 HOUR

EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR)

PDB 4ZAU (AZD9291 COMPLEX WITH WILD TYPE EGFR)

LIGAND CODE = YY3 (link to the list of PDB complexes)

Download experimental 3D coordinates of YY3 with added hydrogens

Epidermal growth factor receptor UNIPROT P00533 EGFR

more at DrugCentral

EMA

ANSM (in French)

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Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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