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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| OSIMERTINIB
| OSIMERTINIB | ANTINEOPLASTIC | ORAL | Tmax 6 HOUR VD 986 LITER Cl 14.2 LITER / HOUR HT 48 HOUR | EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) PDB 4ZAU (AZD9291 COMPLEX WITH WILD TYPE EGFR) LIGAND CODE = YY3 (link to the list of PDB complexes) Download experimental 3D coordinates of YY3 with added hydrogens | KINASE EGFR_HUMAN INHIBITOR P00533 | ANSM (in French) | |||
