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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
LESINURAD DISCONTINUED

LESINURAD


ATC M04AB05

MUSCULO-SKELETAL
URAT1 INHIBITOR (KI = 7.3 MICROMOLAR)
TREATMENT OF HYPERURICEMIA ASSOCIATED WITH GOUT
REDUCES SERUM URIC ACID LEVELS BY INHIBITING THE FUNCTION OF TRANSPORTER PROTEINS INVOLVED IN URIC ACID REABSORPTION IN THE KIDNEY

ORAL

Cmax 14.8 MICROMOLAR

Tmax 2.5 HOUR

F 100 PERCENT

VD 20 LITER

PPB 98 PERCENT

Cl 6 LITER / HOUR

HT 5 HOUR

SOLUBILITY SOLUBLE IN WATER

URIC ACID TRANSPORTER 1 (URAT1)
ORGANIC ANION TRANSPORTER 4 (OAT4)

TRANSPORTER S22AC_HUMAN INHIBITOR Q96S37ANSM (in French)

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