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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
TENOFOVIR ALAFENAMIDE (has an active metabolite)

TENOFOVIR ALAFENAMIDE


ATC J05AR17
ATC J05AF13
ATC J05AR20
ATC J05AR19

ANTIINFECTIVES
TREATMENT OF HIV-1 INFECTION
CONVERTED IN VIVO TO TENOFOVIR

ORAL

Cmax 0.33 MICROMOLAR

Tmax 1 HOUR

PPB 80 PERCENT

HT 0.51 HOUR

SOLUBILITY 4.7 MILLIGRAM / MILLILITER

HIV REVERSE TRANSCRIPTASE

HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE INHIBITOR CHEMBL247 HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE Q72547 REVERSE TRANSCRIPTASE/RNASEH HUMAN IMMUNODEFICIENCY VIRUS 1 ENZYME HYDROLASEANSM (in French)

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