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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ROLAPITANT
| ROLAPITANT | NERVOUS SYSTEM | ORAL INTRAVENOUS | Cmax 1.9 MICROMOLAR Tmax 4 HOUR VD 460 LITER PPB 99.8 PERCENT Cl 0.96 LITER / HOUR HT 176 HOUR | P/NEUROKININ-1 (NK1) RECEPTOR | Substance-P receptor UNIPROT P25103 TACR1 more at DrugCentral | EMA | |||
