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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| COBIMETINIB
| COBIMETINIB | ANTINEOPLASTIC | ORAL | Cmax 514 NANOMOLAR Tmax 2.4 HOUR F 46 PERCENT VD 806 LITER PPB 95 PERCENT Cl 13.8 LITER / HOUR HT 44 HOUR | MAPK MEK1 MEK2 PDB 4AN2 (CRYSTAL STRUCTURES OF HUMAN MEK1 WITH CARBOXAMIDE-BASED ALLOSTERIC INHIBITOR XL518 (GDC-0973), OR RELATED ANALOGS.) LIGAND CODE = EUI (link to the list of PDB complexes) Download experimental 3D coordinates of EUI with added hydrogens | Dual specificity mitogen-activated protein kinase kinase 1 UNIPROT Q02750 MAP2K1 more at DrugCentral | EMA | |||
