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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
BRIVARACETAM

BRIVARACETAM


ATC N03AX23

NERVOUS SYSTEM
TREATMENT OF PARTIAL-ONSET SEIZURES
ANTIEPILEPTIC
HIGH AND SELECTIVE AFFINITY FOR SYNAPTIC VESICLE PROTEIN 2A (SV2A) IN THE BRAIN

ORAL INTRAVENOUS

Tmax 1 HOUR

VD 32.5 LITER (65 KILOGRAM)

PPB 20 PERCENT

HT 9 HOUR

SOLUBILITY VERY SOLUBLE IN WATER

SYNAPTIC VESICLE GLYCOPROTEIN 2A (SV2A)

PDB 4V11 (SYNAPTOTAGMIN-1 WITH SV2A PEPTIDE PHOSPHORYLATED AT THR84)

TRANSPORTER SV2A_HUMAN MODULATOR Q7L0J3ANSM (in French)

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