Cheminformatic Tools and Databases for Pharmacology

session 89238 - Total of 2 hits - Display   hits per page:

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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
CARIPRAZINE (has an active metabolite)

CARIPRAZINE


ATC N05AX15

NERVOUS SYSTEM
ANTIPSYCHOTIC
TREATMENT OF SCHIZOPHRENIA
PARTIAL AGONIST DOPAMINE D2 RECEPTOR (KI = 0.49 NANOMOLAR)
PARTIAL AGONIST SEROTONIN 5-HT1A RECEPTOR (KI = 2.6 NANOMOLAR)
ANTAGONIST 5-HT2A RECEPTOR (KI = 18.8 NANOMOLAR)
HISTAMINE H1 RECEPTOR (KI = 23.2 NANOMOLAR)

ORAL

Cmax 20 NANOMOLAR

Tmax 4.5 HOUR

PPB 94 PERCENT

HT 72 HOUR

DOPAMINE D2 RECEPTOR
5-HT1A RECEPTOR

GPCR 5HT2A_HUMAN ANTAGONIST P28223 DRD2_HUMAN PARTIAL AGONIST P14416 5HT1A_HUMAN PARTIAL AGONIST P08908ANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank

2 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
M CARIPRAZINE (is an active metabolite)

CARIPRAZINE


ATC N05AX15

NERVOUS SYSTEM
ANTIPSYCHOTIC
TREATMENT OF SCHIZOPHRENIA
PARTIAL AGONIST DOPAMINE D2 RECEPTOR
PARTIAL AGONIST SEROTONIN 5-HT1A RECEPTOR
ANTAGONIST 5-HT2A RECEPTOR
HISTAMINE H1 RECEPTOR

-

Cmax 10 NANOMOLAR

PPB 94 PERCENT

DOPAMINE D2 RECEPTOR
5-HT1A RECEPTOR

GPCR 5HT2A_HUMAN ANTAGONIST P28223 DRD2_HUMAN PARTIAL AGONIST P14416 5HT1A_HUMAN PARTIAL AGONIST P08908ANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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