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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| CARIPRAZINE (has an active metabolite)
| CARIPRAZINE | NERVOUS SYSTEM | ORAL | Cmax 20 NANOMOLAR Tmax 4.5 HOUR PPB 94 PERCENT HT 72 HOUR | DOPAMINE D2 RECEPTOR 5-HT1A RECEPTOR PDB 7VOD (CRYSTAL STRUCTURE OF 5-HT2AR IN COMPLEX WITH CARIPRAZINE) LIGAND CODE = 7RU (link to the list of PDB complexes) Download experimental 3D coordinates of 7RU with added hydrogens | D(2) dopamine receptor UNIPROT P14416 DRD2 -- 5-hydroxytryptamine receptor 1A UNIPROT P08908 HTR1A more at DrugCentral | EMA | |||
