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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
SACUBITRIL (has an active metabolite)

SACUBITRIL


ATC C09DX04

CARDIOVASCULAR
NEUTRAL ENDOPEPTIDASE NEPRILYSIN (NEP) INHIBITOR
TREATMENT OF PATIENTS WITH CHRONIC HEART FAILURE

ORAL

Tmax 0.5 HOUR

F 60 PERCENT

VD 103 LITER

PPB 94 PERCENT

Cl 51 LITER / HOUR (EQN)

HT 1.4 HOUR

NEPRILYSIN

NEPRILYSIN INHIBITOR CHEMBL1944 NEPRILYSIN P08473 NEPRILYSIN HOMO SAPIENS ENZYME PROTEASE METALLO MAE M13ANSM (in French)

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