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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
IVABRADINE

IVABRADINE


ATC C01EB17
ATC C07FX06
ATC C07FX05

CARDIOVASCULAR
HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL BLOCKER

ORAL

Tmax 1 HOUR

F 40 PERCENT

VD 100 LITER

PPB 70 PERCENT

Cl 24 LITER / HOUR

HT 6 HOUR

HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED (HCN) CHANNEL

POTASSIUM/SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 1 O60741 POTASSIUM/SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 1 HOMO SAPIENS ION CHANNEL VGC C-GMPANSM (in French)

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