Cheminformatic Tools and Databases for Pharmacology

session 9660 - Total of 1 hits - Display   hits per page:

Add another drug(s) by one keyword:
Exemple: “nib“ and click on the Search button (do not press Enter on the keyboard)

1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
BREXPIPRAZOLE

BREXPIPRAZOLE


ATC N05AX16

NERVOUS SYSTEM
ANTIPSYCHOTIC
TREATMENT OF MAJOR DEPRESSIVE DISORDER OR SCHIZOPHRENIA
COMBINATION OF PARTIAL AGONIST ACTIVITY AT SEROTONIN 5-HT1A (KD = 0.12 NANOMOLAR) AND DOPAMINE D2 (KD = 0.30 NANOMOLAR) AND ANTAGONIST ACTIVITY AT SEROTONIN 5-HT2A RECEPTORS (KD= 0.47 NANOMOLAR)

ORAL

Tmax 4 HOUR

F 95 PERCENT

VD 101.4 LITER (65 KILOGRAM)

PPB 99 PERCENT

Cl 1.28 LITER / HOUR (65 KILOGRAM)

HT 91 HOUR

5-HT1A RECEPTORS
DOPAMINE D2 RECEPTOR
5-HT2A RECEPTOR

SEROTONIN 1A (5-HT1A) RECEPTOR PARTIAL AGONIST CHEMBL214 SEROTONIN 1A (5-HT1A) RECEPTOR P08908 5-HYDROXYTRYPTAMINE RECEPTOR 1A HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 SMALLMOL MONOAMINE RECEPTOR SEROTONIN RECEPTORANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



Copyright © 2019 Université Côte d'Azur CNRS - All rights reserved
  | Contact |