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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M THIOGUANINE (is an active metabolite)
| THIOGUANINE | ANTINEOPLASTIC | - | IMP DEHYDROGENASE GLUTAMINE-5-PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE | Inosine-5-monophosphate dehydrogenase 1 UNIPROT P20839 IMPDH1 -- Inosine-5-monophosphate dehydrogenase 2 UNIPROT P12268 IMPDH2 more at DrugCentral | EMA | ||||
