| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M CYTARABINE (is an active metabolite)
| CYTARABINE | ANTINEOPLASTIC | - | DNA POLYMERASE PDB 6DW3 (SAMHD1 BOUND TO CYTARABINE-TP IN THE CATALYTIC POCKET) LIGAND CODE = HF4 (link to the list of PDB complexes) Download experimental 3D coordinates of HF4 with added hydrogens | DNA polymerase (alpha,delta,epsilon) UNIPROT P09884 POLA1 more at DrugCentral | EMA | ||||
