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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
PALBOCICLIB

PALBOCICLIB


ATC L01XE33

ANTINEOPLASTIC
TREATMENT OF BREAST CANCER
CYCLIN-DEPENDENT KINASE (CDK) INHIBITORS

ORAL

Tmax 9 HOUR

F 46 PERCENT

VD 2583 LITER

PPB 85 PERCENT

Cl 63.1 LITER / HOUR

HT 29 HOUR

SOLUBILITY ABOVE PH4 THE SOLUBILITY REDUCES SIGNIFICANTLY

CYCLIN-DEPENDENT KINASE (CDK) 4
CYCLIN-DEPENDENT KINASE (CDK) 6

PDB 2EUF (X-RAY STRUCTURE OF HUMAN CDK6-VCYCLIN IN COMPLEX WITH THE INHIBITOR PD0332991)

LIGAND CODE = LQQ (link to the list of PDB complexes)

Download experimental 3D coordinates of LQQ with added hydrogens

CDK4/CYCLIN D1 INHIBITOR CHEMBL1907601 CYCLIN-DEPENDENT KINASE 4/CYCLIN D1 P11802 CYCLIN-DEPENDENT KINASE 4 HOMO SAPIENS ENZYME KINASE PROTEIN KINASE CMGCANSM (in French)

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