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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| AVIBACTAM
| AVIBACTAM | ANTIINFECTIVES | INTRAVENOUS | Cmax 57.3 MICROMOLAR VD 23.2 LITER PPB 6.9 PERCENT Cl 11.9 LITER / HOUR HT 2.22 HOUR | BETA LACTAMASE PDB 4S2N (OXA-48) LIGAND CODE = FYG (link to the list of PDB complexes) Download experimental 3D coordinates of FYG with added hydrogens | Beta-lactamase UNIPROT P05364 ampC -- Beta-lactamase UNIPROT P24735 ampC more at DrugCentral | EMA | |||
