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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| NINTEDANIB
| NINTEDANIB | IMMUNOSUPPRESSANT | ORAL | Tmax 3 HOUR F 4.7 PERCENT VD 1050 LITER PPB 97.8 PERCENT Cl 83.4 LITER / HOUR HT 9.5 HOUR | VEGFR PDGFR FGFR PDB 5MAF (CRYSTAL STRUCTURE OF MELK IN COMPLEX WITH AN INHIBITOR) LIGAND CODE = XIN (link to the list of PDB complexes) Download experimental 3D coordinates of XIN with added hydrogens | Platelet-derived growth factor receptor beta UNIPROT P09619 PDGFRB -- Fibroblast growth factor receptor 3 UNIPROT P22607 FGFR3 more at DrugCentral | EMA | |||
