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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| CERITINIB
| CERITINIB | ANTINEOPLASTIC | ORAL | Tmax 5 HOUR VD 4230 LITER PPB 97 PERCENT Cl 33.2 LITER / HOUR HT 41 HOUR | ALK TYROSINE KINASE PDB 4MKC (CRYSTAL STRUCTURE OF ANAPLASTIC LYMPHOMA KINASE COMPLEXED WITH LDK378) LIGAND CODE = 4MK (link to the list of PDB complexes) Download experimental 3D coordinates of 4MK with added hydrogens | ALK tyrosine kinase receptor UNIPROT Q9UM73 ALK more at DrugCentral | EMA | |||
