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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TASIMELTEON
| TASIMELTEON | NERVOUS SYSTEM | ORAL | Tmax 1.75 HOUR F 38.3 PERCENT VD 92.5 LITER PPB 90 PERCENT Cl 49.3 LITER / HOUR (EQN) HT 1.3 HOUR SOLUBILITY SLIGHTLY SOLUBLE IN WATER | MELATONIN MT1 RECEPTOR MELATONIN MT2 RECEPTOR | Melatonin receptor type 1A UNIPROT P48039 MTNR1A -- Melatonin receptor type 1B UNIPROT P49286 MTNR1B more at DrugCentral | EMA | |||
