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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
DASABUVIR

DASABUVIR


ATC J05AX16
ATC J05AX66
ATC J05AP09
ATC J05AP52

ANTIINFECTIVES
TREATMENT OF GENOTYPE 1 CHRONIC HEPATITIS C VIRUS (HCV)
HEPATITIS C VIRUS NON-NUCLEOSIDE NS5B PALM POLYMERASE INHIBITOR

ORAL

Cmax 1.35 MICROMOLAR

Tmax 4.5 HOUR

F 70 PERCENT

VD 396 LITER

PPB 99.5 PERCENT

Cl 47.7 LITER / HOUR (EQN)

HT 5.75 HOUR

SOLUBILITY SLIGHTLY SOLUBLE IN WATER

HCV NON-NUCLEOSIDE NS5B PALM POLYMERASE

HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE INHIBITOR CHEMBL5375 HEPATITIS C VIRUS NS5B RNA-DEPENDENT RNA POLYMERASE Q8JXU8 NS5B PROTEIN HEPATITIS C VIRUS ENZYME TRANSFERASEANSM (in French)

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