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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
IDELALISIB

IDELALISIB


ATC L01EM01

ANTINEOPLASTIC
PHOSPHOINOSITIDE 3-KINASE INHIBITOR
TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA (CLL), RELAPSED FOLLICULAR B-CELL NON-HODGKIN LYMPHOMA AND RELAPSED SMALL LYMPHOCYTIC LYMPHOMA (SLL)
INDUCE APOPTOSIS

ORAL

Tmax 1.5 HOUR

VD 23 LITER

PPB 84 PERCENT

Cl 14.9 LITER / HOUR

HT 8.2 HOUR

SOLUBILITY PH-DEPENDENT AQUEOUS SOLUBILITY 0.1 MILLIGRAM / MILLILITER (PH 5-7)

PHOSPHOINOSITIDE 3-KINASE DELTA

PDB 4XE0 (IDELALISIB BOUND TO THE P110 SUBUNIT OF PI3K DELTA)

LIGAND CODE = 40L (link to the list of PDB complexes)

Download experimental 3D coordinates of 40L with added hydrogens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform UNIPROT O00329 PIK3CD

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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