Cheminformatic Tools and Databases for Pharmacology

session 71984 - Total of 1 hits - Display   hits per page:

Add another drug(s) by one keyword:
Exemple: “nib“ and click on the Search button (do not press Enter on the keyboard)

1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
IDELALISIB

IDELALISIB


ATC L01XX47

ANTINEOPLASTIC
PHOSPHOINOSITIDE 3-KINASE INHIBITOR
TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA (CLL), RELAPSED FOLLICULAR B-CELL NON-HODGKIN LYMPHOMA AND RELAPSED SMALL LYMPHOCYTIC LYMPHOMA (SLL)
INDUCE APOPTOSIS

ORAL

Tmax 1.5 HOUR

VD 23 LITER

PPB 84 PERCENT

Cl 14.9 LITER / HOUR

HT 8.2 HOUR

SOLUBILITY PH-DEPENDENT AQUEOUS SOLUBILITY 0.1 MILLIGRAM / MILLILITER (PH 5-7)

PHOSPHOINOSITIDE 3-KINASE DELTA

PDB 4XE0 (IDELALISIB BOUND TO THE P110 SUBUNIT OF PI3K DELTA)

LIGAND CODE = 40L (link to the list of PDB complexes)

Download experimental 3D coordinates of 40L with added hydrogens

PI3-KINASE P110-DELTA SUBUNIT INHIBITOR CHEMBL3130 PI3-KINASE P110-DELTA SUBUNIT O00329 PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM HOMO SAPIENS ENZYMEANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



Copyright © 2019 Université Côte d'Azur CNRS - All rights reserved
  | Contact |