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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
BELINOSTAT

BELINOSTAT


ATC L01XX49

ANTINEOPLASTIC
HISTONE DEACETYLASE (HDAC) INHIBITOR
TREATMENT OF T-CELL LYMPHOMA (PTCL)

INTRAVENOUS

VD 40 LITER

PPB 94.3 PERCENT

Cl 74.4 LITER / HOUR

HT 1.1 HOUR

SOLUBILITY SLIGHTLY SOLUBLE IN DISTILLED WATER (0.14 MILLIGRAM / MILLILITER)

HISTONE DEACETYLASE (HDAC)

PDB 5EEN (CRYSTAL STRUCTURE OF DANIO RERIO HISTONE DEACETYLASE 6 CATALYTIC DOMAIN 2 IN COMPLEX WITH BELINOSTAT)

LIGAND CODE = 5OG (link to the list of PDB complexes)

Download experimental 3D coordinates of 5OG with added hydrogens

HISTONE DEACETYLASE INHIBITOR CHEMBL2093865 HISTONE DEACETYLASE O15379 HISTONE DEACETYLASE 3 HOMO SAPIENS EPIGENETIC REGULATOR ERASER HDAC HDAC CLASS IANSM (in French)

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