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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
ELIGLUSTAT

ELIGLUSTAT


ATC A16AX10

METABOLISM
A GLUCOSYLCERAMIDE SYNTHASE INHIBITOR
LONG-TERM TREATMENT OF ADULT PATIENTS WITH GAUCHER DISEASE TYPE 1
RESEMBLES THE CERAMIDE SUBSTRATE

ORAL

Cmax 339 NANOMOLAR

Tmax 3 HOUR

VD 835 LITER

PPB 79.5 PERCENT

Cl 88 LITER / HOUR

HT 8.9 HOUR

GLUCOSYLCERAMIDE SYNTHASE

CERAMIDE GLUCOSYLTRANSFERASE INHIBITOR CHEMBL2063 CERAMIDE GLUCOSYLTRANSFERASE Q16739 CERAMIDE GLUCOSYLTRANSFERASE HOMO SAPIENS ENZYME TRANSFERASEANSM (in French)

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