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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
NALOXEGOL

NALOXEGOL


ATC A06AH03

METABOLISM
OPIOID ANTAGONIST
TREATMENT OF OPIOID-INDUCED CONSTIPATION
PEGYLATED DERIVATIVE OF NALOXONE
CNS PENETRATION OF NALOXEGOL IS EXPECTED TO BE NEGLIGIBLE

ORAL

Tmax 2 HOUR

VD 1554 LITER

PPB 4.2 PERCENT

Cl 126 LITER / HOUR (EQN)

HT 8.5 HOUR

SOLUBILITY HIGH AQUEOUS SOLUBILITY ACROSS THE PHYSIOLOGIC PH RANGE

MU-OPIOID RECEPTOR

MU OPIOID RECEPTOR ANTAGONIST CHEMBL233 MU OPIOID RECEPTOR P35372 MU-TYPE OPIOID RECEPTOR HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 PEPTIDE SHORT PEPTIDE OPIOID RECEPTORANSM (in French)

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