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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
PERAMIVIR

PERAMIVIR


ATC J05AH03

ANTIINFECTIVES
INFLUENZA VIRUS NEURAMINIDASE INHIBITOR

INTRAVENOUS

Cmax 142.6 MICROMOLAR

Tmax 0.5 HOUR

VD 12.5 LITER

PPB 30 PERCENT

Cl 0.43 LITER / HOUR (EQN)

HT 20 HOUR

NEURAMINIDASE

PDB 3K39 (CRYSTAL STRUCTURE OF B/PERTH NEURAMINIDASE D197E MUTANT IN COMPLEX WITH PERAMIVIR)

LIGAND CODE = BCZ (link to the list of PDB complexes)

Download experimental 3D coordinates of BCZ with added hydrogens

NEURAMINIDASE INHIBITOR CHEMBL2051 NEURAMINIDASE P03468 NEURAMINIDASE INFLUENZA A VIRUS (A/PUERTO RICO/8/1934(H1N1)) ENZYME HYDROLASEANSM (in French)

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