| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| SUVOREXANT
| SUVOREXANT | NERVOUS SYSTEM | ORAL | Tmax 2 HOUR F 82 PERCENT VD 49 LITER PPB 99 PERCENT Cl 2.8 LITER / HOUR (EQN) HT 12 HOUR SOLUBILITY INSOLUBLE IN WATER | OREXIN RECEPTOR OX1R OREXIN RECEPTOR OX2R PDB OBSOLETE (- 4RNB CRYSTAL STRUCTURE OF THE HUMAN OX2 OREXIN RECEPTOR BOUND TO THE INSOMNIA DRUG SUVOREXANT) LIGAND CODE = SUV (link to the list of PDB complexes) Download experimental 3D coordinates of SUV with added hydrogens | Orexin receptor type 1 UNIPROT O43613 HCRTR1 -- Orexin receptor type 2 UNIPROT O43614 HCRTR2 more at DrugCentral | EMA | |||
