| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| EMPAGLIFLOZIN
| EMPAGLIFLOZIN |
METABOLISM | ORAL | Cmax 687 NANOMOLAR Tmax 1.5 HOUR VD 73.8 LITER PPB 86.2 PERCENT Cl 10.6 LITER / HOUR HT 12.4 HOUR SOLUBILITY VERY SLIGHTLY SOLUBLE IN WATER | SODIUM-GLUCOSE CO-TRANSPORTER2 (SGLT2) PDB 7Y0B (CRYSTAL STRUCTURE OF HUMAN SHORT-CHAIN ACYL-COA DEHYDROGENASE) LIGAND CODE = 7R3 (link to the list of PDB complexes) Download experimental 3D coordinates of 7R3 with added hydrogens | Sodium,glucose cotransporter 2 UNIPROT P31639 SLC5A2 more at DrugCentral | EMA | |||
