Cheminformatic Tools and Databases for Pharmacology

session 45804 - Total of 1 hits - Display   hits per page:

Add another drug(s) by one keyword:
Exemple: “nib“ and click on the Search button (do not press Enter on the keyboard)

1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
APREMILAST

APREMILAST


ATC L04AA32

ANTINEOPLASTIC AND IMMUNODULATING AGENT
INHIBITOR OF PHOSPHODIEASTERASE 4 (PDE4)
TREATMENT OF PSORIATIC ARTHRITIS

ORAL

Tmax 2.5 HOUR

F 73 PERCENT

VD 87 LITER

PPB 68 PERCENT

Cl 10 LITER / HOUR

HT 7.5 HOUR

PHOSPHODIEASTERASE 4 (PDE4)

PDB 7CBQ (CRYSTAL STRUCTURE OF PDE4D CATALYTIC DOMAIN IN COMPLEX WITH APREMILAST)

LIGAND CODE = A9L (link to the list of PDB complexes)

Download experimental 3D coordinates of A9L with added hydrogens

PHOSPHODIESTERASE 4 INHIBITOR CHEMBL2093863 PHOSPHODIESTERASE 4 P27815 CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4A HOMO SAPIENS ENZYME PHOSPHODIESTERASE PDE_4 PDE_4AANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



Copyright © 2019 Université Côte d'Azur CNRS - All rights reserved
  | Contact |