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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
ORITAVANCIN

ORITAVANCIN


ATC J01XA05

ANTIINFECTIVES
LIPOGLYCOPEPTIDE ANTIBACTERIAL
TREATMENT OF ADULT PATIENTS WITH ACUTE BACTERIAL SKIN AND SKIN STRUCTURE INFECTIONS
BINDING TO THE STEM PEPTIDE OF PEPTIDOGLYCAN PRECURSORS DURING CELL WALL BIOSYNTHESIS
DISRUPTION OF BACTERIAL MEMBRANE INTEGRITY

INTRAVENOUS

Cmax 77 MICROMOLAR

VD 87.6 LITER

PPB 85 PERCENT

Cl 0.445 LITER / HOUR

HT 245 HOUR

PEPTIDOGLYCAN PRECURSORS

PEPTIDOGLYCAN INHIBITOR CHEMBL3041361 PEPTIDOGLYCAN BACTERIAANSM (in French)

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