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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
EFINACONAZOLE

EFINACONAZOLE


ATC D01AC19

ANTIINFECTIVES
AZOLE ANTIFUNGAL INDICATED FOR THE TOPICAL TREATMENT OF ONYCHOMYCOSIS OF THE TOENAILS DUE TO TRICHOPHYTON RUBRUM AND TRICHOPHYTON MENTAGROPHYTES
INHIBITS FUNGAL LANOSTEROL 14 ALPHA-DEMETHYLASE

TOPICAL

Cmax 1.9 NANOMOLAR

HT 29.9 HOUR

LANOSTEROL 14 ALPHA DEMETHYLASE

LANOSTEROL 14-ALPHA DEMETHYLASE INHIBITOR CHEMBL3307221 LANOSTEROL 14-ALPHA DEMETHYLASE F2SHH3 UNCHARACTERIZED PROTEIN TRICHOPHYTON RUBRUM (STRAIN ATCC MYA-4607 / CBS 118892) (ATHLETE'SFOOT FUNGUS) UNCLASSIFIEDANSM (in French)

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