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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
DALBAVANCIN

DALBAVANCIN


ATC J01XA04

ANTIINFECTIVES
TREATMENT OF FOR ACUTE BACTERIAL SKIN AND SKIN STRUCTURE INFECTIONS
LIPOGLYCOPEPTIDE SYNTHESIZED FROM A FERMENTATION PRODUCT OF NONOMURAEA SPECIES
A MIXTURE OF FIVE CLOSELY RELATED ACTIVE HOMOLOGS (A0, A1, B0, B1 AND B2)
B0 IS THE MAJOR COMPONENT OF DALBAVANCIN
INTERFERES WITH CELL WALL SYNTHESIS BY BINDING TO THE D-ALANYL-D-ALANINE TERMINUS OF THE STEM PENTAPEPTIDE IN NASCENT CELL WALL PEPTIDOGLYCAN

INTRAVENOUS

Cmax 158 MICROMOLAR (1000 MILLIGRAM)

VD 25.6 LITER (EQN)

PPB 93 PERCENT

Cl 0.0513 LITER / HOUR

HT 346 HOUR

PEPTIDOGLYCAN PRECURSORS

PDB 3RUL (A CARRIER PROTEIN STRATEGY YIELDS THE STRUCTURE OF DALBAVANCIN)

PEPTIDOGLYCAN INHIBITOR CHEMBL3041361 PEPTIDOGLYCAN BACTERIAANSM (in French)

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