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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
VORAPAXAR

VORAPAXAR


ATC B01AC26

BLOOD
PROTEASE-ACTIVATED RECEPTOR-1 (PAR-1) ANTAGONIST
REDUCTION OF THROMBOTIC CARDIOVASCULAR EVENTS
INHIBITOR OF PLATELET AGGREGATION
ITS LONG HALF-LIFE MAKES IT EFFECTIVELY IRREVERSIBLE

ORAL

Tmax 1 HOUR

F 100 PERCENT

VD 424 LITER

PPB 99 PERCENT

Cl 1.5 LITER / HOUR (EQN)

HT 192 HOUR

SOLUBILITY SLIGHTLY SOLUBLE IN WATER AT PH 1

PROTEASE-ACTIVATED RECEPTOR-1 (PAR-1)

PDB 3VW7 (CRYSTAL STRUCTURE OF HUMAN PROTEASE-ACTIVATED RECEPTOR 1 (PAR1) BOUND WITH ANTAGONIST VORAPAXAR AT 2.2 ANGSTROM)

LIGAND CODE = VPX (link to the list of PDB complexes)

Download experimental 3D coordinates of VPX with added hydrogens

PROTEINASE-ACTIVATED RECEPTOR 1 ANTAGONIST CHEMBL3974 PROTEINASE-ACTIVATED RECEPTOR 1 P25116 PROTEINASE-ACTIVATED RECEPTOR 1 HOMO SAPIENS MEMBRANE RECEPTOR 7TM1 PEPTIDE PROTEASE-ACTIVATED RECEPTOR PROTEASE-ACTIVATED RECEPTORANSM (in French)

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