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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M SULINDAC (is an active metabolite)
| SULINDAC | MUSCULO-SKELETAL | - | Tmax 4.96 HOUR PPB 97.9 PERCENT HT 16.4 HOUR | PROSTAGLANDIN G/H SYNTHASE 1 PROSTAGLANDIN G/H SYNTHASE 2 PDB 4XUH (PPARGAMMA LIGAND BINDING DOMAIN IN COMPLEX WITH SULINDAC SULFIDE) LIGAND CODE = SFI (link to the list of PDB complexes) Download experimental 3D coordinates of SFI with added hydrogens | Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 more at DrugCentral | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that the equation t1/2 = VD / Cl * 0.693 was used | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| SULINDAC (has an active metabolite)
| SULINDAC | MUSCULO-SKELETAL | ORAL | Cmax 9.8 MICROMOLAR Tmax 2.5 HOUR F 90 PERCENT VD 170.2 LITER PPB 93.1 PERCENT Cl 20.2 LITER / HOUR HT 7.28 HOUR SOLUBILITY VERY SOLUBLE AS THE SODIUM SALT OR IN BUFFERS OF PH 6 OR HIGHER | PROSTAGLANDIN G/H SYNTHASE 1 PROSTAGLANDIN G/H SYNTHASE 2 PDB 2KAW (NMR STRUCTURE OF THE MDVL1 PDZ DOMAIN IN COMPLEX WITH ITS INHIBITOR) LIGAND CODE = SUZ (link to the list of PDB complexes) Download experimental 3D coordinates of SUZ with added hydrogens | Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 more at DrugCentral | EMA | |||
