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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M FLUTAMIDE (is an active metabolite)
| FLUTAMIDE | ANTINEOPLASTIC | - | Cmax 7.8 MICROMOLAR Tmax 2 HOUR PPB 93 PERCENT HT 6 HOUR | ANDROGEN RECEPTOR PDB 4OH6 (CRYSTAL STRUCTURE OF T877A-AR-LBD BOUND WITH CO-REGULATOR PEPTIDE) LIGAND CODE = HFT (link to the list of PDB complexes) Download experimental 3D coordinates of HFT with added hydrogens | Androgen receptor UNIPROT P10275 AR more at DrugCentral | EMA | |||
