| | ||||||||||
| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M MISOPROSTOL (is an active metabolite)
| MISOPROSTOL |
METABOLISM | - | Cmax 2.2 NANOMOLAR Tmax 0.2 HOUR PPB 90 PERCENT HT 0.5 HOUR | PROSTAGLANDIN RECEPTOR PDB 6M9T (CRYSTAL STRUCTURE OF EP3 RECEPTOR BOUND TO MISOPROSTOL-FA) LIGAND CODE = J9P (link to the list of PDB complexes) Download experimental 3D coordinates of J9P with added hydrogens | Prostaglandin E2 receptor EP3 subtype UNIPROT P43115 PTGER3 more at DrugCentral | EMA | |||
