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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M NABUMETONE (is an active metabolite)
| NABUMETONE | MUSCULO-SKELETAL | - | Tmax 2.5 HOUR VD 53.4 LITER PPB 99 PERCENT Cl 1.26 LITER / HOUR HT 26.2 HOUR | PROSTAGLANDIN G/H SYNTHASE 1 PROSTAGLANDIN G/H SYNTHASE 2 PDB 6U5A (CRYSTAL STRUCTURE OF EQUINE SERUM ALBUMIN COMPLEX WITH 6-MNA) LIGAND CODE = PWY (link to the list of PDB complexes) Download experimental 3D coordinates of PWY with added hydrogens | Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2 more at DrugCentral | EMA | |||
