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session 97697 - Total of 2 hits - Display   hits per page:

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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
M SIMVASTATIN (is an active metabolite)

SIMVASTATIN


ATC C10AA01
ATC C10BX01
ATC C10BA02
ATC C10BA04
ATC C10BX04
ATC A10BH51

CARDIOVASCULAR
HYPOCHOLESTEROLEMIC
ANTILIPEMIC AGENTS
HYDROXYMETHYLGLUTARYL-COA (HMG-COA) REDUCTASE INHIBITORS
STATIN

-

Cmax 7.5 NANOMOLAR

Tmax 6.5 HOUR

PPB 95 PERCENT

HT 4.8 HOUR

3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA)

PDB 1HW9 (COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH SIMVASTATIN)

LIGAND CODE = SIM (link to the list of PDB complexes)

Download experimental 3D coordinates of SIM with added hydrogens

HMG-COA REDUCTASE INHIBITOR CHEMBL402 HMG-COA REDUCTASE P04035 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE HOMO SAPIENS ENZYME REDUCTASEANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank

2 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
SIMVASTATIN (has an active metabolite)

SIMVASTATIN


ATC C10AA01
ATC C10BX01
ATC C10BA02
ATC C10BA04
ATC C10BX04
ATC A10BH51

CARDIOVASCULAR
HYPOCHOLESTEROLEMIC
ANTILIPEMIC AGENTS
HYDROXYMETHYLGLUTARYL-COA (HMG-COA) REDUCTASE INHIBITORS
STATIN

ORAL

Tmax 4 HOUR

F 5 PERCENT

PPB 95 PERCENT

HT 4.5 HOUR

SOLUBILITY PRACTICALLY INSOLUBLE IN WATER

3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA)

HMG-COA REDUCTASE INHIBITOR CHEMBL402 HMG-COA REDUCTASE P04035 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE HOMO SAPIENS ENZYME REDUCTASEANSM (in French)

Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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