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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| M SIMVASTATIN (is an active metabolite)
| SIMVASTATIN |
CARDIOVASCULAR | - | Cmax 7.5 NANOMOLAR Tmax 6.5 HOUR PPB 95 PERCENT HT 4.8 HOUR | 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA) PDB 1HW9 (COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH SIMVASTATIN) LIGAND CODE = SIM (link to the list of PDB complexes) Download experimental 3D coordinates of SIM with added hydrogens | 3-hydroxy-3-methylglutaryl-coenzyme A reductase UNIPROT P04035 HMGCR more at DrugCentral | EMA | |||
