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1 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
CLOMIPRAMINE (has an active metabolite)

CLOMIPRAMINE


ATC N06AA04

NERVOUS SYSTEM
ANTIDEPRESSANT
ANTIOBSESSIONAL
SEROTONIN UPTAKE INHIBITORS

ORAL

Cmax 693 NANOMOLAR

Tmax 4 HOUR

VD 845 LITER (65 KILOGRAM)

PPB 97 PERCENT

Cl 31.9 LITER / HOUR (65 KILOGRAM)

HT 32 HOUR

SOLUBILITY FREELY SOLUBLE IN WATER

SEROTONIN TRANSPORTER

PDB 4MMA (CRYSTAL STRUCTURE OF LEUBAT (DELTA13 MUTANT) IN COMPLEX WITH CLOMIPRAMINE)

LIGAND CODE = CXX (link to the list of PDB complexes)

Download experimental 3D coordinates of CXX with added hydrogens

Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank

2 INNClassRoute (list)PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693)Primary Target and PDB code of Protein-Drug complexTargets from DrugCentral Links
M CLOMIPRAMINE (is an active metabolite)

CLOMIPRAMINE


ATC N06AA04

NERVOUS SYSTEM
ANTIDEPRESSANT
ANTIOBSESSIONAL
SEROTONIN UPTAKE INHIBITORS

-

Cmax 912 NANOMOLAR

HT 69 HOUR

SEROTONIN TRANSPORTER

Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4 -- Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2

more at DrugCentral

EMA

ANSM (in French)

Inxight Drugs
Dailymed
Drugs.com

SIDER side effects

Chemical Probes Portal

ChEMBL
BindingDB
DrugBank



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